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Recombinant Human PVRIG (C-mFc) (RPES6378)

SKU:
RPES6378
Product Type:
Recombinant Protein
Species:
Human
€229
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Description

Product Name:Recombinant Human PVRIG (C-mFc)
Product Code:RPES6378
Size:10µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:C7orf15, CD112R, PVRIG, transmembrane protein PVRIG, C7orf15MGC138295, MGC104322, MGC138297, MGC2463
Mol Mass:40.6 kDa
AP Mol Mass:45-50 kDa
Tag:C-Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Immobilized Human PVRIG-Fc at 10μg/ml (100 μl/well) can bind Human Nectin-2-His. The ED50 of Human Nectin-2-His is 2. 914 ug/ml.
Sequence:Thr41-Asp171
Accession:Q6DKI7
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

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