Human PCSK9 Recombinant Protein (RPES2891)
- SKU:
- RPES2891
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
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Description
system_update_altDatasheet
Human PCSK9 Recombinant Protein
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2); and play a role in the neural development.
| Product Name: | Human PCSK9 Recombinant Protein (RPES2891) |
| Product Code: | RPES2891 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1 |
| Accession: | Q8NBP7 |
| Sequence: | Gln31-Gln152&Ser153-Gln692 |
| Fusion tag: | C-6His/HA/AVI |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His/HA/AVI tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14&59 |
| AP Mol Mass: | 18&70 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 50mM HEPES;150mM NaCl;20%Glycerol;pH 7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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