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Human Noggin/NOG Recombinant Protein (RPES0723)

SKU:
RPES0723
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Growth Factors & Cytokines
$283
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Description

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Human Noggin/NOG Recombinant Protein

Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). N-terminal acidic region, a central basic heparin-binding segment, and a C-terminal cysteine knot structure are all present in Mature Human Noggin. Among vertebrates, Noggin is well conserved; thus, mature human Noggin has 99%; 99%; 98%; and 89% aa sequence identity with mouse; rat bovine; equine and chicken Noggin, respectively. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds BMPs with distinct affinities. Some, such as BMP4, are highly bound, whereas others, such as BMP7, are less so. It antagonizes BMP bioactivities by binding to epitopes on BMPs required for both type I and type II receptors binding. Noggin is found in specific regions of the adult central nervous system and peripheral tissues including lung, skeletal muscle, and skin. Under certain conditions, culture of human embryonic stem cells (hESC) or neural stem cells may be induced; Noggin can be used to block BMP activity in order for stem cells to proliferate while keeping their unspecialized state. Alternatively, dopaminergic neurons may differentiate from stem cells. Human Noggin/NOG Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.