Human NMNAT1/NMNAT Recombinant Protein (RPES1536)
- SKU:
- RPES1536
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Frequently bought together:
Description
system_update_altDatasheet
Human NMNAT1/NMNAT Recombinant Protein
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enzyme is vital for NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
| Product Name: | Human NMNAT1/NMNAT Recombinant Protein (RPES1536) |
| Product Code: | RPES1536 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | LCA9,NMNAT,PNAT1 |
| Accession: | Q9HAN9 |
| Sequence: | Met 1-Thr 279 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human NMNAT1 (Q9HAN9)( Met 1-Thr279) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 33.3 kDa |
| AP Mol Mass: | 34 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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