NKG2D ligand 1; also called ULBP1; is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess ?1; ?2 and ?3 domains; ULBP/RAET1 family members lack ?3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells; and then promotes the lysis of cells expressing ULBP1 which is important for the immune surveillance. ULBP1 and several other family members; ULBP2 and ULBP5; own the ability to bind the human cytomegalovirus (CMV) UL16 glycoprotein. The human CMV glycoprotein UL16 binds to intracellular ULBP1 and so inhibits its expression at the cell surface; which reduces the susceptibility of the virus-infected cell to cytotoxic destruction by NK cells. The expression of ULBP1 has been found on some tumor cells and is implicated in tumor surveillance.
Product Name:
Human NKG2DL/ULBP Recombinant Protein (RPES0587)
Product Code:
RPES0587
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
NKG2D ligand 1,NKG2DL1,ALCAN-beta,Retinoic acid early transcript 1I,UL16-binding protein 1,ULBP1
Accession:
Q9BZM6
Sequence:
Gly26-Pro215
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human UL16 Binding Protein-1/NKG2D ligand 1 is produced by our Mammalian expression system and the target gene encoding Gly26-Pro215 is expressed with a Fc tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
49.4 kDa
AP Mol Mass:
58-70 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
