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Recombinant Human MHC class I polypeptide-related sequence A/MIC-A Protein (RPCB0286)

SKU:
RPCB0286
Size:
10µg
Tag:
C-His
Reactivity:
Human
Expression Host:
HEK293 cells
€99
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Description

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Product Name:Recombinant Human MHC class I polypeptide-related sequence A/MIC-A Protein
SKU:RPCB0286
Size:10µg
Tag:C-His
Reactivity:Human
Expression Host:HEK293 cells
Protein Description:High quality, high purity and low endotoxin recombinant Recombinant Human MHC class I polypeptide-related sequence A/MIC-A Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed.
Endotoxin:< 0.1 EU/μg of the protein by LAL method.
Purity:> 95% by SDS-PAGE.
Formulation:Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Gene ID:100507436

MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to MHC class I family. It is the member of the non-classical class I family that displays the greatest degree of polymorphism. The MICA protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma.

Storage:Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Reconstitution:Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
Swiss-Prot:Q29983
Product ImageRecombinant Human MIC-A Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 55-65 kDa. .
Product ImageImmobilized Recombinant Human MICA Protein at 2 μg/mL (100 μL/well) can bind NKG2D with a linear range of 0.61-14.3 ng/mL.

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