Human LRP10 Recombinant Protein (RPES4325)
- SKU:
- RPES4325
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
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Description
system_update_altDatasheet
Human LRP10 Recombinant Protein
Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN); plasma membrane (PM); and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.
| Product Name: | Human LRP10 Recombinant Protein (RPES4325) |
| Product Code: | RPES4325 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | LRP9,MST087,MSTP087 |
| Accession: | Q7Z4F1-1 |
| Sequence: | Met 1-Lys 440 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human LRP10 (Q7Z4F1-1) extracellular domain (Met 1-Lys 440) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 47.5kDa |
| AP Mol Mass: | 60 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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