Human KYNU/Kynureninase Recombinant Protein (RPES0483)
- SKU:
- RPES0483
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
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Description
system_update_altDatasheet
Human KYNU/Kynureninase Recombinant Protein
Kynureninase is an enzyme that cuts L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively, using pyridoxal phosphate as a substrate. Kynureninase is required for the generation of NAD cofactors from tryptophan via the kynurenine pathway. Two metabolic diseases, hydroxykynureninuria and limb defects syndrome 2, are linked to kynureninase. Human KYNU/Kynureninase Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human KYNU/Kynureninase Recombinant Protein (RPES0483) |
| Product Code: | RPES0483 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | KYNUU |
| Accession: | Q16719 |
| Sequence: | Met 1- Asn 465 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 200 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human KYNU (Q16719) (Met 1- Asn 465) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | > 92 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 53.7 kDa |
| AP Mol Mass: | 47 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 25% gly |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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