Human Kallikrein 7/KLK7 Recombinant Protein (RPES3940)
- SKU:
- RPES3940
- Product Type:
- Recombinant Protein
- Species:
- Human
Frequently bought together:
Description
system_update_altDatasheet
Human Kallikrein 7/KLK7 Recombinant Protein
Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.
Product Name: | Human Kallikrein 7/KLK7 Recombinant Protein (RPES3940) |
Product Code: | RPES3940 |
Size: | 10µg |
Species: | Human |
Expressed Host: | Human Cells |
Synonyms: | Kallikrein-7, hK7, Serine Protease 6, Stratum Corneum Chymotryptic Enzyme, hSCCE, KLK7, PRSS6, SCCE |
Accession: | P49862 |
Sequence: | Glu23-His252 |
Fusion tag: | C-6His |
Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
Protein Construction: | Recombinant Human Kallikrein 7 is produced by our Mammalian expression system and the target gene encoding Glu23-His252 is expressed with a 6His tag at the C-terminus. |
Purity: | > 95 % as determined by reducing SDS-PAGE. |
Mol Mass: | 26.2 kDa |
AP Mol Mass: | 30 kDa |
Formulation: | Supplied as a 0.2 µm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5. |
Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |