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Human JAM-A/F11R Recombinant Protein (RPES0503)

SKU:
RPES0503
Product Type:
Recombinant Protein
Species:
Human
€656
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Description

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Human JAM-A/F11R Recombinant Protein

Junctional adhesion molecule-A (JAM-A); also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321); is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.

Product Name:Human JAM-A/F11R Recombinant Protein (RPES0503)
Product Code:RPES0503
Size:50µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:Junctional Adhesion Molecule A, JAM-A, Junctional Adhesion Molecule 1, JAM-1, Platelet F11 Receptor, Platelet Adhesion Molecule 1, PAM-1, CD321, F11R, JAM1, JCAM,JAMA,JCAM,KAT
Accession:NP_058642.1
Sequence:Met 1-Ala 242
Fusion tag:C-His
Activity:Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8 x 104 cells/well are added to JAM-A-Fc coated plates (2.5µg/mL; 100 ?L/well)in the presence of 20 ng/mL PMA; approximately 30-40% will adhere after 30 minutes at 37?.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the extracellular domain (Met 1-Ala 242) of human JAM-A (NP_058642.1) precursor was expressed with a polyhistidine tag at the C-terminus.
Purity:> 97 % as determined by reducing SDS-PAGE.
Mol Mass:25 kDa
AP Mol Mass:28-32 kDa
Formulation:Lyophilized from sterile PBS; pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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