Human Interleukin7F/IL7F Recombinant Protein (RPES2082)
- SKU:
- RPES2082
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
Human Interleukin7F/IL7F Recombinant Protein
Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated; but not resting; CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines; including IL-6; IL-8; and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2; TGFB1/TGFB; and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).
| Product Name: | Human Interleukin7F/IL7F Recombinant Protein (RPES2082) |
| Product Code: | RPES2082 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-17F, IL-17F, Cytokine ML-1, Interleukin-24, IL-24, IL17F, IL24 |
| Accession: | Q96PD4 |
| Sequence: | Arg31-Gln163 |
| Fusion tag: | C-6His |
| Activity: | Measured by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 21.87 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-17F is produced by our Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 16.0 kDa |
| AP Mol Mass: | 19 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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