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Human Interleukin-4/IL-4 Recombinant Protein (RPES2483)

SKU:
RPES2483
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Growth Factors & Cytokines
€236
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Description

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Human Interleukin-4/IL-4 Recombinant Protein

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation; survival and gene expression. IL-4 is produced by mast cells; T cells; and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells; characterized by their cytokine-secretion profile that includes secretion of IL-4; IL-5; IL-6; IL-10; and IL-13; which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.

Product Name:Human Interleukin-4/IL-4 Recombinant Protein (RPES2483)
Product Code:RPES2483
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Interleukin-4, IL-4, B-Cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4
Accession:P05112
Sequence:His25-Ser153
Fusion tag:C-6His
Activity:Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.2 ng/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Interleukin-4 is produced by our Mammalian expression system and the target gene encoding His25-Ser153 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:16.0 kDa
AP Mol Mass:18 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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