IL-1 receptor-like 1 (IL1RL1) is a membrane protein that plays a role in TH2 inflammatory responses and eosinophilia. It has been noted that the IL1RL1 protein level may be used to diagnose cardiovascular illness and predict a patient's prognosis in patients with cardiovascular disease. The ligand for IL1RL1, which has been dubbed IL-33, has been identified. Blood eosinophil counts and asthma have both been linked to variations in IL1RL1 in genome-wide association studies and family-based and case-control studies. This cytokine has been linked to the regulation of both the formation and effector phases of type 2 helper T cell responses, as well as macrophage pro-inflammatory function. It is an important mediator in several immune and inflammatory processes. ST2L binds to the IL33 receptor and activates it, causing Th2 cytokines to be produced. Human IL1RL1/ST2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human IL1RL1/ST2 Recombinant Protein (RPES0392)
Product Code:
RPES0392
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
DER4,FIT-1,IL1RL1,IL33R,IL?1 ,R4,ST2,ST2L,ST2V,T1
Accession:
NP_003847.2
Sequence:
Met 1-Phe 328
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
The secreted isoform of human IL1RL1 (NP_003847.2) (Met 1-Phe 328) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
35.6 kDa
AP Mol Mass:
55-60 kDa
Formulation:
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
