Interleukin 1 family member 5 (IL-1F5); also known as interleukin 36 receptor antagonist (IL36RA), is a type of interleukin 1 cytokine. This cytokine was found to specifically block the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A); beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1); which is present in epithelial barriers and takes part in local inflammatory response. It has been demonstrated in vitro that IL-1F5 increases the expression of IL-4 mRNA and protein in glial cells, as well as increasing hippocampal IL-4 expression following intracerebroventricular injection. IL-1F5 also blocks LPS-induced IL-1 beta in cells from IL-4-deficient mice. Results of the study suggest that the anti-inflammatory effects of IL-1F5 are mediated by its capacity to stimulate IL-4 production, which is due to its interaction with the orphan receptor; single Ig IL-1R-related molecule (SIGIRR)/TIR8; as they were not observed in SIGIRR -/- mice. In contrast to its effects on brain tissue, IL-1F5 had no effect on LPS-induced changes; up-regulated IL-4 in macrophages and dendritic cells; suggesting that the impact is limited to the brain. Human IL1F5/IL36RN Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human IL1F5/IL36RN Recombinant Protein (RPES1716)
Product Code:
RPES1716
Size:
20µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Interleukin-36 Receptor Antagonist Protein, FIL1 Delta, IL-1-Related Protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1, Interleukin-1 Delta, IL-1 Delta, Interleukin-1 Family Member 5, IL-1F5, Interleukin-1 Receptor Antagonist Homolog 1, IL-1ra Homolog 1, Interleukin-1-Like Protein 1, IL-1L1, IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3
Accession:
Q9UBH0
Sequence:
Met 1-Asp155
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the mature form of human IL1F5 (Q9UBH0) (Met1-Asp155) was expressed.
Purity:
> 99 % as determined by reducing SDS-PAGE.
Mol Mass:
17.1 kDa
AP Mol Mass:
18 kDa
Formulation:
Lyophilized from sterile PBS
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
