Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Product Name:
Human IL beta/IL1B Recombinant Protein (RPES0237)
Product Code:
RPES0237
Size:
20µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
IL-1,IL-1 beta,IL-1B,IL1-BETA,IL1F2
Accession:
NP_000567.1
Sequence:
Met 1-Ser 269
Fusion tag:
N-His
Activity:
Measured by its binding ability in a functional ELISA. Immobilized human IL1B at 10 µg/mL (100 ?l/well) can bind human IL1RThe EC50 of human IL1R1 is 0.198 µg/mL.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the pro form of human IL1? (NP_000567.1) (Met 1-Ser 269) was fused with a polyhistidine tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
32.3 kDa
AP Mol Mass:
34 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
