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Recombinant Human IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-Avi-6His) Biotinylated (RPES6303)

SKU:
RPES6303
Product Type:
Recombinant Protein
Species:
Human
€549

Description

Product Name:Recombinant Human IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-Avi-6His) Biotinylated
Product Code:RPES6303
Size:20µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:Interleukin-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6R 1, Membrane glycoprotein 80, gp80, CD126
Mol Mass:41.2 kDa
AP Mol Mass:65-85 kDa
Tag:C-Avi-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Testing in progress
Sequence:Leu20-Pro365
Accession:P08887
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

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