Human ICOS/AILIM Recombinant Protein (RPES2009)
- SKU:
- RPES2009
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Frequently bought together:
Description
system_update_altDatasheet
Human ICOS/AILIM Recombinant Protein
Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige
| Product Name: | Human ICOS/AILIM Recombinant Protein (RPES2009) |
| Product Code: | RPES2009 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Inducible T-cell costimulator,activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1,ICOS, |
| Accession: | Q9Y6W8 |
| Sequence: | Glu21-Phe141 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human ICOS is produced by our Mammalian expression system and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 40.8 kDa |
| AP Mol Mass: | 47 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4 . |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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