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Recombinant Human Granzyme B/CTLA-1/GZMB Protein (RPCB1880)

SKU:
RPCB1880
Size:
10µg
Tag:
C-His
Reactivity:
Human
€209
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Description

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Product Name:Recombinant Human Granzyme B/CTLA-1/GZMB Protein
SKU:RPCB1880
Size:10µg
Tag:C-His
Reactivity:Human
Protein Description:High quality, high purity and low endotoxin recombinant Recombinant Human Granzyme B/CTLA-1/GZMB Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed.
Endotoxin:<1EU/μg
Purity:>97% as determined by SDS-PAGE
Formulation:Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene ID:3002

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

Storage:Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Reconstitution:Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
Swiss-Prot:P10144
Product ImageRecombinant Bovine FSH/CGA&FSHB Protein was determined by SDS- PAGE with Coomassie Blue, showing a band at 35-40 kDa.

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