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Human GITR/TNFRSF18 Recombinant Protein (RPES2510)

SKU:
RPES2510
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death
€221
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Description

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Human GITR/TNFRSF18 Recombinant Protein

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Product Name:Human GITR/TNFRSF18 Recombinant Protein (RPES2510)
Product Code:RPES2510
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Tumor necrosis factor receptor superfamily member 18, TNFRSF18, Glucocorticoid-induced TNFR-related protein, CD357, TNFRSF18, AITR, GITR
Accession:Q9Y5U5
Sequence:Gln26-Glu161(Thr45Ala)
Fusion tag:C-mFc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant human GITR is produced by our Mammalian expression system and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mFc tag at the C-terminus.
Purity:> 90% as determined by reducing SDS-PAGE.
Mol Mass:41.1 kDa
AP Mol Mass:40-55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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