TNFRSF21 (death receptor-6; DR6) is an orphan TNF receptor superfamily member and belongs to the death receptors subgroup. A type I transmembrane protein has four extracellular cysteine-rich motifs and a cytoplasmic death domain. N- and O-glycosylations of amino acids in its extracellular portion, as well as the extensive posttranslational modification of the transmembrane protein DR6. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain; and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production; suggested that DR6 serves as an important regulatory molecule in T-helper cell activation; and is involved in inflammation and immune regulation. DR6 is expressed in virtually all tissues, with the highest levels seen in lymphoid organs, the heart, the brain and the pancreas. Tumor cells may express excessive levels of DR6, which is often seen in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion; which is subject to future investigations. Human DR6/TNFRSF21 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human DR6/TNFRSF21 Recombinant Protein (RPES0911)
Product Code:
RPES0911
Size:
100µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Tumor Necrosis Factor Receptor Superfamily Member 21, Death Receptor 6, CD358, TNFRSF21, DR6
Accession:
NP_055267.1
Sequence:
Met 1-Leu 350
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
The mature form of human DR6 (NP_055267.1) extracellular domain (Met 1-Leu 350) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
34.2 kDa
Formulation:
Lyophilized from sterile 100mM NaCl; 50mM Tris; pH 7.5
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
