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Recombinant Human DC-SIGNR/CD299 (N-8His-Flag)

SKU:
RPES6338
Product Type:
Recombinant Protein
Species:
Human
$311
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Description

Product Name:Recombinant Human DC-SIGNR/CD299 (N-8His-Flag)
Product Code:RPES6338
Size:10µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:CD209L, CD209L1, CD299, CLEC4M, C-type lectin domain family 4, member M, DC-SIGN2, DCSIGNR, DC-SIGNR, HP10347, LSIGN, L-SIGN, C-type Lectin Domain Family 4 Member M
Mol Mass:37 kDa
AP Mol Mass:35-40 kDa
Tag:N-8His-Flag
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Testing in progress
Sequence:Ser73-Glu376
Accession:Q9H2X3-8
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.

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