Chitotriosidase is a cytosolic ester hydrolase enzyme that is generated by activated human macrophages and is significantly more abundant in Gaucher disease patients' plasma. In cultures, chitotriosidase activity is only detected late in the monocyte differentiation to activated macrophages process. A human macrophage may create a functional chitotriosidase, which is a highly conserved protein with a tightly regulated production. CHIT1 may be involved in the breakdown of chitin-containing organisms, according to a study. Several CHIT1 variant transcripts have been identified. Gaucher's disease and chitotriosidase deficiency are two examples of diseases influenced by CHIT1. Glycosaminoglycan metabolism and the innate immune system are pathways connected to CHIT1. Human Chitotriosidase/CHIT1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Chitotriosidase/CHIT1 Recombinant Protein (RPES0470)
Recombinant Human Chitotriosidase-1 is produced by our Mammalian expression system and the target gene encoding Ala22-Asn466 is expressed with a 6His tag at the C-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
50.4 kDa
AP Mol Mass:
54 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
