null

Human CDCP1/CD318 Recombinant Protein (RPES1511)

SKU:
RPES1511
Product Type:
Recombinant Protein
Species:
Human
$283
Frequently bought together:

Description

system_update_altDatasheet

Human CDCP1/CD318 Recombinant Protein

CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains; and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues; but its phosphorylation is only seen in mitotically detached or shedding cells; consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA; or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.