Human CDCP1/CD318 Recombinant Protein (RPES1511)
- SKU:
- RPES1511
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
Human CDCP1/CD318 Recombinant Protein
CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains; and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues; but its phosphorylation is only seen in mitotically detached or shedding cells; consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA; or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.
| Product Name: | Human CDCP1/CD318 Recombinant Protein (RPES1511) |
| Product Code: | RPES1511 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | CUB domain-containing protein 1,Membrane glycoprotein gp140,Subtractive immunization M plus HEp3-associated 135 kDa protein,SIMA135,Transmembrane and associated with src kinases,CD318,TRASK |
| Accession: | Q9H5V8-3 |
| Sequence: | Phe30-Ser341 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human CUB domain-containing protein 1 is produced by our Mammalian expression system and the target gene encoding Phe30-Ser341 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 36.1 kDa |
| AP Mol Mass: | 55 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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