Recombinant Human CD30 Ligand/TNFSF8 Protein (His Tag) (RPES8382)
- SKU:
- RPES8382
- Size:
- 20μg
- Tag:
- C-His
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- P32971
Description
| Product Name: | Recombinant Human CD30 Ligand/TNFSF8 Protein (His Tag) |
| SKU: | RPES8382 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | P32971 |
| Sequence: | Val63-Asp234 |
| Calculated Molecular Weight: | 18.8 kDa |
| Observed Molecular Weight: | 40 kDa |
| Synonyms: | PSOR, CD antigen CD, Tumor necrosis factor ligand superfamily member, TNFSF, S100A, TNFSF8, CD153, CD30L, CD30LG, TNLG3A, CD antigen CD153, CD30 ligand, CD30-L, sCD30 Ligand, soluble CD30 Ligand, Tumor necrosis factor ligand superfamily member 8, S100A7, PSOR1, S100A7C, TNFSF8 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals throμgh CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been sμggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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