The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Product Name:
Human CD200R1 Recombinant Protein (RPES2779)
Product Code:
RPES2779
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
CD200R,HCRTR2,MOX2R,OX2R
Accession:
AAI43394.1
Sequence:
Met 1-Leu 266
Fusion tag:
C-His & Fc
Activity:
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1 µg/ml (100ul/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human CD200R1 (AAI43394.1) extracellular doamin (Met 1-Leu 266) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Purity:
> 94 % as determined by reducing SDS-PAGE.
Mol Mass:
54.9 kDa
AP Mol Mass:
90-100 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
