Human Cathepsin L/CTSL Recombinant Protein (RPES4674)
- SKU:
- RPES4674
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
Recombinant Human Cathepsin L/CTSL Protein (His Tag)
| Background: | Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts and is also one of the major acidic cysteine proteases in mammalian cells. |
| Name: | Recombinant Human Cathepsin L/CTSL Protein (His Tag) |
| Size: | 10µg |
| Assay Genie SKU: | RPES4674 |
| Synonyms: | Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL |
| Species: | Human |
| Expression host: | Human Cells |
| Sequence: | Thr18-Val333 |
| Accession: | P07711 |
| Mol Mass: | 36.9 kDa |
| AP Mol Mass: | 34 kDa |
| Tag: | C-6His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin: | < 1.0 EU per µg as determined by the LAL method. |
| Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Formulation: | Supplied as a 0.2 um filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.5. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| UniProt Protein Function: | Important for the overall degradation of proteins in lysosomes. |
| NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P07711 |
| NCBI GenInfo Identifier: | 115741 |
| NCBI Gene ID: | 1514 |
| NCBI Accession: | P07711.2 |
| UniProt Secondary Accession: | P07711,Q6IAV1, Q96QJ0, |
| UniProt Related Accession: | P07711 |
| Molecular Weight: | 38kDa |
| NCBI Full Name: | Cathepsin L1 |
| NCBI Synonym Full Names: | cathepsin L |
| NCBI Official Symbol: | CTSL |
| NCBI Official Synonym Symbols: | MEP; CATL; CTSL1 |
| NCBI Protein Information: | cathepsin L1 |
| UniProt Protein Name: | Cathepsin L1 |
| UniProt Synonym Protein Names: | Cathepsin L; Major excreted protein; MEP |
| UniProt Gene Name: | CTSL |
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