Calreticulin is a widely conserved chaperone protein that functions in several cellular activities, such as cell adhesion, and is found in the endoplasmic reticulum. Calreticulin/CRT helps to keep calcium homeostasis and protein folding quality in check. Calreticulin is also present in the nucleus, implying that it may be involved with transcription regulation. Abnormal increases in serum autoantibodies against calreticulin are associated with systemic lupus erythematosus. Calreticulin abnormalities have been associated with a range of tumours, including myeloproliferative neoplasms. CRT/Calreticulin is a protein that participates in the HIV life cycle and protein metabolism. Human CALR/Calreticulin Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human CALR/Calreticulin Recombinant Protein (RPES3863)
Product Code:
RPES3863
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
cC1qR,CRT,HEL-S-99n,RO,SSA
Accession:
P27797
Sequence:
Met 1-Ala413
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human CALR (P27797) (Met1-Ala413) was expressed with a polyhistidine tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
47.4 kDa
AP Mol Mass:
58 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
