Recombinant Human AXL/UFO Protein (Fc Tag) (RPES8335)
- SKU:
- RPES8335
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- P30530
Description
| Product Name: | Recombinant Human AXL/UFO Protein (Fc Tag) |
| SKU: | RPES8335 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | P30530 |
| Sequence: | Ala26–Trp451 |
| Calculated Molecular Weight: | 71.7 kDa |
| Observed Molecular Weight: | 90-100 kDa |
| Synonyms: | JTK, Tyro, AXL, ARK, JTK11, Tyro7, UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Axl receptor tyrosine kinase , together with Tyro3 and Mer , constitute the TAM family of receptor tyrosine kinases. In the nervous system , Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response , regulating cytokine secretion , clearing apoptotic cells and debris , and maintaining cell survival. Axl is upregulated in various disease states , such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions , suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival , migration , invasion , metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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