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Human Autotaxin/ENPP2 Recombinant Protein (RPES3012)

SKU:
RPES3012
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
€236
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Description

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Human Autotaxin/ENPP2 Recombinant Protein

ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain.Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.

Product Name:Human Autotaxin/ENPP2 Recombinant Protein (RPES3012)
Product Code:RPES3012
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:ATX, ATXFLJ26803, ATX-X, Autotaxin, autotaxin-t, EC 3.1.4.39, ectonucleotide pyrophosphatase/phosphodiesterase 2,E-NPP 2, ENPP2, LysoPLD, NPP2, PD-IALPHA, PDNP2, PDNP2NPP2
Accession:Q13822
Sequence:Ala36-Ile863
Fusion tag:C-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human ENPP2 is produced by our Mammalian expression system and the target gene encoding Ala36-Ile863 is expressed with a 6His tag at the C-terminus.
Purity:> 90% as determined by reducing SDS-PAGE.
Mol Mass:90 kDa
AP Mol Mass:100-120 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mMPB,150mMNaCl,pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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