Recombinant Human AIF1 Protein(Trx Tag) (RPES8115)
- SKU:
- RPES8115
- Size:
- 20μg
- Tag:
- N-Trx
- Reactivity:
- Human
- Expression Host:
- E.coli
- Accession:
- P55008-1
Description
| Product Name: | Recombinant Human AIF1 Protein (Trx Tag) |
| SKU: | RPES8115 |
| Size: | 20μg |
| Tag: | N-Trx |
| Reactivity: | Human |
| Expression Host: | E.coli |
| Accession: | P55008-1 |
| Sequence: | Met1-Pro147 |
| Calculated Molecular Weight: | 36 kDa |
| Observed Molecular Weight: | 36 kDa |
| Endotoxin: | < 10 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. It is expressed in macrophages and neutrophils. AIF1 enhances membrane ruffling and RAC activation. AIF1 enhances the actin-bundling activity of LCP1. It also enhances lymphocyte migration. AIF1 may play a role in macrophage activation and function. It binds calcium and plays a role in RAC signaling and in phagocytosis. It promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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