Recombinant Cynomolgus LILRA4/ILT-7/CD85g Protein (RPCB1758)
- SKU:
- RPCB1758
- Size:
- 100µg
- Tag:
- C-His
- Reactivity:
- Cynomolgus
- Expression Host:
- HEK293 cells
Description
| Product Name: | Recombinant Cynomolgus LILRA4/ILT-7/CD85g Protein |
| SKU: | RPCB1758 |
| Size: | 100µg |
| Tag: | C-His |
| Reactivity: | Cynomolgus |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Cynomolgus LILRA4/ILT-7/CD85g Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | Less than 1EU per μg by the LAL method. |
| Purity: | > 95% as determined by Tris-Bis PAGEï¼›> 95% as determined by HPLC |
LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | XP_005590346.1 |
 | Cynomolgus LILRA4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
 | The purity of Cynomolgus LILRA4 is greater than 95% as determined by SEC-HPLC. |
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