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Recombinant Cynomolgus BCMA/TNFRSF17 (C-6His)

SKU:
RPES6776
Product Type:
Recombinant Protein
Species:
Monkey
$275
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Description

Product Name:Recombinant Cynomolgus BCMA/TNFRSF17 (C-6His)
Product Code:RPES6776
Size:10µg
Species:Cynomolgus macaques
Expression Host:HEK293 Cells
Synonyms:Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein, CD269, Tnfrsf17, Bcm, Bcma
Mol Mass:7 kDa
AP Mol Mass:12&15-20 kDa
Tag:C-6His
Purity:> 90 % as determined by reducing SDS-PAGE.
Endotoxin Level:< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:Testing in progress
Sequence:Met1-Ala53
Accession:G7Q0I4
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the
Reconstitution:Please refer to the printed manual for detailed information.
Background:B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.

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