Cavia porcellus CTLA-4/CD152 Recombinant Protein (RPES4219)
- SKU:
- RPES4219
- Product Type:
- Recombinant Protein
- Species:
- Guinea pig
Frequently bought together:
Description
system_update_altDatasheet
Cavia porcellus CTLA-4/CD152 Recombinant Protein
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
| Product Name: | Cavia porcellus CTLA-4/CD152 Recombinant Protein (RPES4219) |
| Product Code: | RPES4219 |
| Size: | 10µg |
| Species: | Cavia porcellus |
| Expressed Host: | P.Pichia |
| Synonyms: | Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4 |
| Accession: | H0VUB1 |
| Sequence: | Ala37-Asp161 |
| Fusion tag: | C-His |
| Activity: | Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1µg/ml(100 ?l/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 14.1 kDa |
| AP Mol Mass: | 18-40 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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