The RECK Polyclonal Antibody (CAB6718) is a valuable tool for researchers studying the RECK protein, a key player in the regulation of matrix metalloproteinases and tumor progression. This antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the RECK protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential tool for studies in cancer research and beyond.RECK, also known as reversion-inducing cysteine-rich protein with kazal motifs, is a critical regulator of extracellular matrix turnover and cell migration, playing a central role in tumor invasion and metastasis.
Its dysregulation has been linked to various types of cancer, making it a promising target for therapeutic interventions. Understanding the function of RECK is crucial for developing treatments that can effectively inhibit tumor progression and improve patient outcomes. Overall, the RECK Polyclonal Antibody (CAB6718) is a reliable and specific tool for researchers seeking to further explore the role of RECK in cancer biology and potential therapeutic strategies.
Product Name:
RECK Rabbit Polyclonal Antibody
SKU:
CAB6718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-210 of human RECK (NP_066934.1).
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RECK antibody (CAB6718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
