The REC8 Antibody (PAC016961) is a high-quality polyclonal antibody designed for research involving the REC8 protein, an essential component of the meiotic recombination process. The antibody, produced in rabbits, is highly specific for REC8 and is validated for use in various experimental applications.REC8 is a key protein involved in the regulation of chromosome segregation during meiosis, playing a critical role in ensuring the proper alignment and separation of homologous chromosomes. Dysregulation of REC8 can lead to chromosomal abnormalities and infertility, making it a valuable target for research in reproductive biology and genetic disorders.
The REC8 Antibody enables precise detection and analysis of REC8 protein expression in different cell types, providing researchers with valuable insights into the molecular mechanisms underlying meiotic recombination. Its high specificity and sensitivity make it an ideal tool for studying the role of REC8 in meiosis and its potential implications for fertility and genetic health.
Antibody Name:
REC8 Antibody (PACO16961)
Antibody SKU:
PACO16961
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human REC8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16961(REC8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16961(REC8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes.
Synonyms:
REC8 meiotic recombination protein
NCBI Summary:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
