The RCAN2 Polyclonal Antibody (PAC052330) is a valuable tool for researchers studying RCAN2, a protein with important roles in calcium signaling and cellular stress response. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. By binding to the RCAN2 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an ideal choice for studies in cell biology and molecular biology.RCAN2, also known as Regulator of calcineurin 2, is involved in modulating the activity of calcineurin, a key regulator of immune response and T cell activation.
Dysregulation of RCAN2 has been implicated in various diseases, including Alzheimer's disease and cardiac hypertrophy. By studying the function of RCAN2, researchers can gain insight into the underlying mechanisms of these conditions and potentially identify new therapeutic targets.Overall, the RCAN2 Polyclonal Antibody is a valuable tool for researchers investigating the role of RCAN2 in various cellular processes and disease states. Its high specificity and versatility make it an essential component of any research project involving RCAN2.
Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: RCAN2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 22, 28 kDa. Observed band size: 22 kDa.
Immunofluorescent analysis of A549 cells using PACO52330 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human brain tissue using PACO52330 at dilution of 1:100.
Background:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Synonyms:
Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4), RCAN2, DSCR1L1 ZAKI4
UniProt Protein Function:
RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p12.3Cellular Component: cytoplasmMolecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
