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RCAN2 Antibody (PACO19177)

SKU:
PACO19177
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407

Description

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RCAN2 Antibody (PACO19177)

The RCAN2 Polyclonal Antibody (PAC019177) is a valuable tool for researchers studying RCAN2, a protein involved in various cellular processes, including calcium signaling and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for Western blot applications. By binding to RCAN2, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for research in molecular biology and biomedical sciences.

RCAN2, also known as DSCR1L2, plays a crucial role in cellular functions such as cell proliferation, differentiation, and apoptosis. Its involvement in calcium signaling pathways and gene transcription makes it a promising target for studying diseases like Alzheimer's, Down syndrome, and cancer. By investigating the role of RCAN2 in these conditions, researchers can gain insights into potential therapeutic targets and pathways for disease intervention and management.

Antibody Name:RCAN2 Antibody (PACO19177)
Antibody SKU:PACO19177
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide of human RCAN2
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19177(RCAN2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms:regulator of calcineurin 2
UniProt Protein Function:RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p12.3Cellular Component: cytoplasmMolecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q14206
NCBI GenInfo Identifier:158958336
NCBI Gene ID:10231
NCBI Accession:Q14206.3
UniProt Secondary Accession:Q14206,Q5VWF7, Q5VWF8, Q8N116, A6ND07, B3KR46
UniProt Related Accession:Q14206
Molecular Weight:27,289 Da
NCBI Full Name:Calcipressin-2
NCBI Synonym Full Names:regulator of calcineurin 2
NCBI Official Symbol:RCAN2  
NCBI Official Synonym Symbols:CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1  
NCBI Protein Information:calcipressin-2
UniProt Protein Name:Calcipressin-2
UniProt Synonym Protein Names:Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
Protein Family:Calcipressin
UniProt Gene Name:RCAN2  
UniProt Entry Name:RCAN2_HUMAN
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