The RC3H2 Polyclonal Antibody (PAC041946) is a valuable tool for researchers studying RC3H2, a protein involved in immune regulation and RNA metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. By specifically binding to the RC3H2 protein, researchers can easily detect and analyze its presence in various cell types, making it ideal for investigations in immunology and cancer research.RC3H2, also known as Roquin-2, is a key player in post-transcriptional gene regulation, impacting processes such as mRNA decay and translation.
Its involvement in immune response modulation suggests its potential as a therapeutic target for diseases like cancer, autoimmune disorders, and inflammatory conditions. By studying RC3H2, researchers can uncover novel insights into immune system function and potentially develop new treatment strategies for immune-related disorders.Overall, the RC3H2 Polyclonal Antibody is a valuable resource for researchers looking to delve into the intricate mechanisms of immune regulation and RNA metabolism, with potential implications for therapeutic development in various disease contexts.
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5.
Synonyms:
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid, binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2), RC3H2, MNAB RNF164
UniProt Protein Function:
MNAB: 6 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; DNA-bindingChromosomal Location of Human Ortholog: 9q34Cellular Component: cell surface; cytoplasm; membrane; nucleoplasmMolecular Function: DNA binding; ligase activity; mRNA binding; ubiquitin-protein ligase activity; zinc ion bindingBiological Process: alveolus development; B cell homeostasis; limb development; lymph node development; multicellular organism growth; post-embryonic development; protein polyubiquitination; spleen development; T cell homeostasis; T cell proliferation
