The RBX1 Polyclonal Antibody (CAB14500) is a valuable tool for researchers studying RBX1, a key component of the SCF E3 ubiquitin ligase complex involved in protein degradation and cell cycle regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the RBX1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential resource for studies in cell biology, cancer research, and the ubiquitin-proteasome pathway.
RBX1 plays a crucial role in regulating the degradation of target proteins by the ubiquitin-proteasome system, making it a potential target for therapeutic interventions in diseases such as cancer and neurodegenerative disorders. By deciphering the functions of RBX1 in cellular processes, researchers can gain insights into its role in disease development and progression, paving the way for the development of novel treatments targeting the ubiquitin-proteasome system.
Product Name:
RBX1 Rabbit Polyclonal Antibody
SKU:
CAB14500
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RBX1 (NP_055063.1).
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
Purification Method:
Affinity purification
Gene ID:
9978
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RBX1 Rabbit pAb (CAB14500) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
