The RBPJK Rabbit Monoclonal Antibody (CAB4081) is a powerful tool for researchers studying the RBPJK protein, a key regulator of gene expression and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the RBPJK protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and cancer research.RBPJK, also known as recombination signal binding protein for immunoglobulin kappa J region, plays a crucial role in controlling gene transcription and cell signaling processes.
Its involvement in various pathways, including the Notch signaling pathway, highlights its importance in development, differentiation, and disease progression. By understanding the function of RBPJK, researchers can uncover valuable insights into pathways related to cancer, stem cell biology, and developmental disorders, paving the way for potential therapeutic targets and interventions.
Product Name:
RBPJK Rabbit Monoclonal Antibody
SKU:
CAB4081
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBPJK (Q06330).
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
Purification Method:
Affinity purification
Gene ID:
3516
Clone Number:
ARC0894
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RBPJK Rabbit mAb (CAB4081) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
