The RBFOX1 Polyclonal Antibody (CAB7811) is a versatile tool for researchers studying RBFOX1, a key RNA-binding protein involved in regulating alternative splicing and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity for RBFOX1 in human samples, making it an ideal choice for Western blotting and immunohistochemistry applications.RBFOX1, also known as Fox-1, is a critical player in RNA processing and splicing events, influencing the production of various protein isoforms with diverse functions.
Dysregulation of RBFOX1 has been linked to neurological disorders, such as autism spectrum disorders and intellectual disabilities, as well as cancer progression. By targeting RBFOX1 with this antibody, researchers can explore its role in disease pathogenesis and potential therapeutic interventions.Unlock the potential of RBFOX1 research with the CAB7811 Polyclonal Antibody, and delve into the intricate mechanisms of RNA metabolism and gene regulation for a deeper understanding of human health and disease.
Product Name:
RBFOX1 Rabbit Polyclonal Antibody
SKU:
CAB7811
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RBFOX1 (NP_665900.1).
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54715
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using RBFOX1 antibody (CAB7811) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
