The RBBP7 Polyclonal Antibody (CAB13456) is specifically designed for research involving RBBP7, a protein implicated in various cellular processes such as chromatin remodeling, gene transcription, and DNA repair. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.RBBP7, also known as Retinoblastoma Binding Protein 7, is a key player in the regulation of gene expression and cell cycle progression. Its involvement in chromatin organization and epigenetic modifications make it a critical target for studies in cancer research and developmental biology.
Understanding the role of RBBP7 can provide valuable insights into the mechanisms underlying tumorigenesis and potential therapeutic interventions.With its high specificity and sensitivity, the RBBP7 Polyclonal Antibody enables precise detection and analysis of RBBP7 protein levels in various cell types and experimental conditions. This makes it an indispensable tool for researchers seeking to unravel the complex functions of RBBP7 in cellular processes and disease pathogenesis.
Product Name:
RBBP7 Rabbit Polyclonal Antibody
SKU:
CAB13456
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RbAp46/RBBP7 (NP_002884.1).
WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 ChIP,5μg antibody for 10μg-15μg of Chromatin
Synonyms:
RbAp46; RbAp46/RBBP7
Positive Sample:
HepG2,NIH/3T3,Mouse placenta,Rat spleen
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
48kDa
Observed MW:
48kDa
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using RbAp46/RBBP7 Rabbit pAb (CAB13456) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
