RB Rabbit Polyclonal Antibody (CAB11409)
- SKU:
- CAB11409
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | RB Rabbit Polyclonal Antibody |
SKU: | CAB11409 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human RB (NP_000312.2). |
Sequence: | MNSL GLVT SNGL PEVE NLSK RYEE IYLK NKDL DARL FLDH DKTL QTDS IDSF ETQR TPRK SNLD EEVN VIPP HTPV RTVM NTIQ QLMM ILNS ASDQ PSEN L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:100 - 1:200 |
Synonyms: | RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1 |
Positive Sample: | Jurkat,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 106kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Purification Method: | Affinity purification |
Gene ID: | 5925 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |