RB Monoclonal Antibody (CAB22663)
- SKU:
- CAB22663
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Frequently bought together:
Description
Product Name: | RB Monoclonal Antibody |
SKU: | CAB22663 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human RB1 (NP_000312.2). |
Sequence: | DSII VFYN SVFM QRLK TNIL QYAS TRPP TLSP IPHI PRSP YKFP SSPL RIPG GNIY ISPL KSPY KISE GLPT PTKM TPRS RILV SIGE SFGT SEKF QKIN Q |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 106kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Purification Method: | Affinity purification |
Gene ID: | 5925 |
Clone Number: | ARC57809 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |