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RB Monoclonal Antibody (CAB22663)

SKU:
CAB22663
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC
€139 - €529
Frequently bought together:

Description

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Product Name:RB Monoclonal Antibody
SKU:CAB22663
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human RB1 (NP_000312.2).
Sequence:DSII VFYN SVFM QRLK TNIL QYAS TRPP TLSP IPHI PRSP YKFP SSPL RIPG GNIY ISPL KSPY KISE GLPT PTKM TPRS RILV SIGE SFGT SEKF QKIN Q
Tested Applications:IHC-P ELISA
Recommended Dilution:IHC-P,1:50 - 1:200
Synonyms:RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:106kDa
Observed MW:Refer to figures

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Purification Method:Affinity purification
Gene ID:5925
Clone Number:ARC57809
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded mouse spleen using RB Rabbit mAb (CAB22663) at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

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