Rat SIRPA Recombinant Protein (RPPB4687)
- SKU:
- RPPB4687
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P97710
Description
| Product Name: | Rat SIRPA Recombinant Protein |
| Product Code: | RPPB4687 |
| Size: | 10µg |
| Species: | Rat |
| Target: | SIRPA |
| Synonyms: | Tyrosine-proteinphosphatase non-receptor type substrate 1, SHP substrate, SHPS-1, Brain Ig-likemolecule with tyrosine-based activation motifs, Bit, CD172 antigen-likefamily member A, Inhibitory receptorSHPS-1, Macrophage fusion receptor, Macrophage membrane protein MFP150, Signal-regulatoryprotein alpha-1, Sirp-alpha-1, CD172a, Sirpa, Bit, Mfr, Ptpns1, Shps1, Sirp. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SIRPA protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | KELKVTQADK SVSVAAGDSA TLNCTVSSLT PVGPIKWFKG EGQNRSPIYSFIGGEHFPRI TNVSDATKRN NMDFSICISN VTPEDAGTYY CVKFQKGIVE PDTEIKSGGG TTLYVLAKPSSPEVSGPDSR GSPGQTVNFT CKSYGFSPRN ITLKWLKNGK ELSHLETTIS SKSNVSYNIS STVSVKLSPE DIHSRVICEVAHVTLEGRPL NGTANFSNII RVSPTLKITQ QPLTPASQVN LTCQVQKFYP KALQLNWLEN GNLSRTDKPE HFTDNRDGTYNYTSLFLVNS SAHREDVVFT CQVEHDSQPA ITENHTVRAF AHSSSGGSME TIPDNNAYYN WNVEHHHHHH |
| UniProt Code: | P97710 |
Signal-Regulatory Protein Alpha, SIRPA belongs to the signal-regulatory-protein (SIRP) family, as well as theimmunoglobulin super family. The members of the SIRP family are receptor-type transmembrane glycoproteins which areinvolved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPA can bephosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2domain containing tyrosine phosphatases (PTP), and perform as substrates of PTPs. SIRPA take part insignal transduction mediated by a variety of growth factor receptors. CD47 has been shown to be a ligand forSIRPA.
SIRPA Rat Recombinant produced in Sf9 Baculovirus cellsis a single, glycosylated polypeptide chain containing 350 amino acids (32-373a.a)and having a molecular mass of 38.5kDa. (Migrates at 57-70kDa on SDS-PAGE underreducing conditions). SIRPA is fused to an 8 amino acid His-tag at C-terminus& purified by proprietary chromatographic techniques.
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