Rat Prolactin Recombinant Protein (RPPB0875)
- SKU:
- RPPB0875
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P01237
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Rat Prolactin Recombinant Protein |
| Product Code: | RPPB0875 |
| Size: | 50µg |
| Species: | Rat |
| Target: | Prolactin |
| Synonyms: | Mammotropin, Luterotropic hormone, Lutetropin, PRL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl. |
| Solubility: | It is recommended to reconstitute the lyophilized Prolactin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prolactin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Val-Cys |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065 ng/ml corresponding to a specific activity of 15,400,000 Units/mg. |
Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation.
Prolactin Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6 kDa. The Prolactin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide Cellular Component: extracellular region; secretory granule Molecular Function:prolactin receptor binding; hormone activity Biological Process: response to drug; circadian rhythm; lactation; maternal behavior; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; response to organic cyclic substance; response to estradiol stimulus; cellular response to hormone stimulus; response to ethanol; regulation of JAK-STAT cascade; ovulation cycle; mammary gland development; positive regulation of cell proliferation; parturition; regulation of ossification; multicellular organismal response to stress; positive regulation of epithelial cell proliferation; response to nutrient; STAT protein nuclear translocation |
| NCBI Summary: | induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006] |
| UniProt Code: | P01237 |
| NCBI GenInfo Identifier: | 130938 |
| NCBI Gene ID: | 24683 |
| NCBI Accession: | P01237.1 |
| UniProt Secondary Accession: | P01237,P70520, |
| UniProt Related Accession: | P01237 |
| Molecular Weight: | 25,753 Da |
| NCBI Full Name: | Prolactin |
| NCBI Synonym Full Names: | prolactin |
| NCBI Official Symbol: | Prl�� |
| NCBI Official Synonym Symbols: | PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1�� |
| NCBI Protein Information: | prolactin; prolactin family 1, subfamily a, member 1 |
| UniProt Protein Name: | Prolactin |
| Protein Family: | Prolactin |
| UniProt Gene Name: | Prl�� |
| UniProt Entry Name: | PRL_RAT |
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