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Rat Pan T-cells monoclonal antibody (FITC) (AGIM0566)

SKU:
AGIM0566
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MRC OX-52
Conjugation:
FITC
Applications:
FC
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Description

system_update_altDatasheet
Product Name:Rat Pan T-cells monoclonal antibody (FITC)
Product Code:AGIM0566
Size:500 µL
Reactivity:Rat
Clone:MRC OX-52
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P30203
UniProt Protein Function:CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane

Molecular Function:protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cell adhesion

NCBI Summary:This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:P30203
NCBI GenInfo Identifier:281185506
NCBI Gene ID:923
NCBI Accession:P30203.3
UniProt Secondary Accession:P30203,Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0, A4KAD4 A4KAD5,
UniProt Related Accession:P30203
Molecular Weight:60,572 Da
NCBI Full Name:T-cell differentiation antigen CD6
NCBI Synonym Full Names:CD6 molecule
NCBI Official Symbol:CD6  
NCBI Official Synonym Symbols:TP120  
NCBI Protein Information:T-cell differentiation antigen CD6; T12; CD6 antigen
UniProt Protein Name:T-cell differentiation antigen CD6
UniProt Synonym Protein Names:T12; TP120; CD_antigen: CD6
Protein Family:T-cell differentiation antigen
UniProt Gene Name:CD6  
UniProt Entry Name:CD6_HUMAN

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