Rat M CSF Recombinant Protein (RPPB0755)
- SKU:
- RPPB0755
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q8JZQ0
- Research Area:
- Growth Factors & Cytokines
Frequently bought together:
Description
| Product Name: | Rat M CSF Recombinant Protein |
| Product Code: | RPPB0755 |
| Size: | 10µg |
| Species: | Rat |
| Target: | M CSF |
| Synonyms: | CSF-1, Lanimostim, MCSF, MGC31930, M-CSF. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The recombinant�MCSF was lyophilized after extensive dialysis against PBS. |
| Solubility: | It is recommended to reconstitute the�MCSF in sterile PBS not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized MCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCSF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Biological Activity: | The ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of mouse M-NFS-60 cells. |
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
MCSF Rat Recombinant produced in HEK-293 cells is a secreted protein (amino acids Glu33-Arg254). M-CSF is disulfide-linked homodimer containing 2 x 222 a.a chains.
| UniProt Protein Function: | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| NCBI Summary: | plays a role in macrophage formation; involved in osteoclastogenesis and endochondral ossification [RGD, Feb 2006] |
| UniProt Code: | Q8JZQ0 |
| NCBI GenInfo Identifier: | 28201782 |
| NCBI Gene ID: | 78965 |
| NCBI Accession: | Q8JZQ0.1 |
| UniProt Related Accession: | Q8JZQ0 |
| Molecular Weight: | 62,187 Da |
| NCBI Full Name: | Macrophage colony-stimulating factor 1 |
| NCBI Synonym Full Names: | colony stimulating factor 1 |
| NCBI Official Symbol: | Csf1�� |
| NCBI Protein Information: | macrophage colony-stimulating factor 1 |
| UniProt Protein Name: | Macrophage colony-stimulating factor 1 |
| Protein Family: | Macrophage colony-stimulating factor |
| UniProt Gene Name: | Csf1�� |
| UniProt Entry Name: | CSF1_RAT |
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